Sitagliptin 50 mg, Glimepiride 2 mg, Metformin 500 mg

Generic Sitagliptin 50 mg + Glimepiride 2 mg + Metformin 500 mg is a prescription combination tablet used for blood sugar management in adults with type 2 diabetes mellitus when two-medicine therapy is not giving adequate control. Doctors choose this combination because it targets glucose control through different actions, which can improve daily stability and reduce repeated spikes.

Metformin helps lower glucose production in the liver and improves insulin sensitivity, so your body uses insulin more effectively. Sitagliptin supports glucose-dependent insulin release and reduces excess glucagon after meals, which helps with post-meal readings. Glimepiride increases insulin release from the pancreas, so it can be effective, but it also increases the risk of low blood sugar if meals are delayed or skipped. That is why regular meal timing matters with this combination.

Most patients take it with food to improve tolerance and reduce stomach upset. Monitor glucose regularly, especially when starting or changing dose. Contact your doctor if you notice repeated low glucose episodes, sweating, shaking, confusion, severe weakness, or fainting. Also report persistent nausea, vomiting, or unusual tiredness. Your doctor may advise periodic kidney tests and overall monitoring for safer long-term use.