Sitagliptin 100 mg, Metformin 500 mg, Pioglitazone 15 mg

Generic Sitagliptin 100 mg + Metformin Hydrochloride 500 mg + Pioglitazone 15 mg is a prescription combination tablet used for blood sugar management in adults with type 2 diabetes mellitus when single or two-medicine therapy is not providing stable control. Doctors prefer this combination because it targets blood sugar from different angles, helping improve fasting control as well as after-meal stability.

Metformin hydrochloride supports glucose control by reducing glucose production in the liver and improving insulin sensitivity. Sitagliptin works in a glucose-dependent way to support insulin release and reduce excess glucagon after meals, which may help smooth post-meal spikes. Pioglitazone further improves insulin sensitivity in muscle and fat tissue, helping the body use insulin more effectively over time. This multi-pathway approach is often chosen for patients who need stronger metabolic support with a fixed-dose routine.

Take this medicine exactly as prescribed, usually with meals to improve tolerance. Follow the diet and activity plan advised by your doctor and monitor glucose regularly. Inform your doctor if you notice persistent swelling in feet, unusual weight gain, shortness of breath, repeated low glucose readings, or severe stomach upset. Periodic monitoring of liver function and overall metabolic health may be advised depending on your medical history.